Virology, Epidemiology, Pathogenesis, and Control of COVID-19

Figure 2


β-coronavirus particle and genome [9]…

Figure 2


β-coronavirus particle and genome [9] ( A ) The β-coronavirus particle. β-coronavirus is…

Figure 2

β-coronavirus particle and genome [9] (A) The β-coronavirus particle. β-coronavirus is an enveloped, nonsegmented, positive-sense single-stranded RNA virus genome in a size ranging from 29.9 kb. The virion has a nucleocapsid composed of genomic RNA and phosphorylated nucleocapsid (N) protein, which is buried inside phospholipid bilayers and covered by the spike glycoprotein trimmer (S). The membrane (M) protein hemagglutinin-esterase (HE) and the envelope (E) protein are located among the S proteins in the virus envelope. (B) 5′ and 3′ terminal sequences of the SARS-CoV-2 genome. The gene order is 5′-replicase ORF1ab-S-envelope(E)-membrane(M)-N-3′. ORF3ab, ORF6, ORF7ab, ORF8, ORF9ab, and ORF10 are located at the predicted positions shown in the picture. 1a, 1b, 3a, 3b, 6, 7a, 7b, 8, 9a, 9b, 10 in the picture represent different ORF genes.


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