Virology, Epidemiology, Pathogenesis, and Control of COVID-19
β-coronavirus particle and genome …
β-coronavirus particle and genome  ( A ) The β-coronavirus particle. β-coronavirus is…
β-coronavirus particle and genome  (A) The β-coronavirus particle. β-coronavirus is an enveloped, nonsegmented, positive-sense single-stranded RNA virus genome in a size ranging from 29.9 kb. The virion has a nucleocapsid composed of genomic RNA and phosphorylated nucleocapsid (N) protein, which is buried inside phospholipid bilayers and covered by the spike glycoprotein trimmer (S). The membrane (M) protein hemagglutinin-esterase (HE) and the envelope (E) protein are located among the S proteins in the virus envelope. (B) 5′ and 3′ terminal sequences of the SARS-CoV-2 genome. The gene order is 5′-replicase ORF1ab-S-envelope(E)-membrane(M)-N-3′. ORF3ab, ORF6, ORF7ab, ORF8, ORF9ab, and ORF10 are located at the predicted positions shown in the picture. 1a, 1b, 3a, 3b, 6, 7a, 7b, 8, 9a, 9b, 10 in the picture represent different ORF genes.